To observe the changes in the local humoral immune factors in the cervix and interventional effects of the “Fengxiang Lotion” on these factors in patients with high-risk HPV infection and CIN I. Methods:Fifty patients with simple high-risk HPV infection (HPV group), 50 patients with high-risk HPV infection associated with CIN I (CIN I group) and 50 healthy women (control group) were selected. In the HPV group and CIN I group, patients were given the TCM “Fengxiang Lotion” as treatment; the vaginal lavage was retained before and after treatment; and the SIgA, IgG and IgE expression levels were detected using ELISA method. Results:Before treatment, the SIgA concentration was significantly lower in the HPV group and CIN I group than that in the control group (P<0.01); the changes were more remarkable in the CIN I group than that in the HPV group (P<0.01); the IgG and IgE concentrations were significantly higher in the HPV group than that in the control group (P<0.01), while the IgG and IgE concentrations were significantly lower in CIN I group than that in the control group (P<0.01); After treatment, there was a significant increase in SIgA concentration (P<0.01) and a significant decrease in IgG and IgE concentrations in the HPV group (P<0.01); After treatment, there were a significant increase in SIgA, IgG and IgE concentrations in the CIN I group (P<0.01); There were no statistically significant difference in post-treatment SIgA, IgG or IgE level between the control group and the HPV or CIN I group (P>0.05). Conclusion:In patients with high-risk HPV infection and CIN I, there are abnormal changes in the local humoral immune factors in cervix, such as SIgA, IgG and IgE, and “Fengxiang Lotion” effectively improves the local humoral immune state in cervix.