To explore the clinical efficacy of Yiqi Huoxue Plaster in the treatment of sepsis patients with qi deficiency and blood stasis pattern and its effects on coagulation indicator. Methods:A total of 79 sepsis patients with qi deficiency and blood stasis pattern who were admitted and treated in Zhengzhou TCM Hospital from May 2014 to March 2016 were selected. All patients were randomly divided into control group (n=39) and observation group (n=40). The control group was treated with conventional western medicine treatment, while the observation group wase treated combined with Yiqi Huoxue Plaster on the basis of conventional treatment. Two groups were treated for 4 weeks continuously. The clinical efficacy and the improvement of clinical symptoms were recorded, and the serum coagulation and anti-coagulation indicators before and after treatment were detected. The physical condition of 2 groups before and after treatment were evaluated and compared. Results:The total effective rate of the patients in the observation group (87.50%) was significantly higher than that of the control group (66.67%) (P<0.05). Compared with the state before treatment, the symptoms integral of shortness of breath, lack of strength, tongue picture in control group decreased significantly after treatment (P<0.01), while the symptoms integral of shortness of breath, lack of strength, mental fatigue, spontaneous sweating and tongue picture in observation group decreased significantly, which was significantly lower than that in control group after treatment (P<0.01). Compared with the state before treatment, the APTT and PT of 2 groups shortened significantly after treatment (P<0.01), and there was no significant difference (P>0.05). The D-D levels of 2 groups decreased significantly, and that of observation group was lower than that of control group (P<0.01). The PLT of observation group increased significantly and higher than that of control group (P<0.05). Compared with the state before treatment, the levels of AT-Ⅲ and APC of 2 groups increased significantly, while the scores of APACHE and SOFA decreased significantly when compared with before treatment, with significant difference (P<0.01). Conclusion:Yiqi Huoxue Plaster can significantly improve the clinical symptoms of qi deficiency and blood stasis pattern of sepsis patients, regulate effectively the coagulation and anti-coagulation indicators, promote the blood coagulation and anticoagulation equilibrium, reduce the blood viscosity, and prevent hemorrhage and thrombosis. The clinical efficacy is superior to conventional western medicine alone.