To explore the efficacy and safety of integrated traditional Chinese and Western medicine in the treatment of ovulatory infertility. Methods:In total, 126 cases of infertility patients who came to our hospital from May 2013 to April in were divided into a treatment group (n=62) and a western medicine group (n=64) according to the treatment method. Endometrial thickness in the two groups before and after treatment were statistically analyzed. The ovulation rate, pregnancy rate, abortion rate and the total effective rate of the two groups were observed and analyzed,and then evaluated combined with the adverse reaction rate for its security. Results:Before treatment, the endometrial thickness of the combined therapy group were compared with western medicine treatment group, and there was no statistically significant difference (P>0.05). After treatment, the endometrial thickness of the combined therapy group was increased compared with that of the western medicine group (P<0.05); The ovulation rate, abortion rate and pregnancy rate of the combination group were higher than those of the simple western medicine group (P<0.05);While the combined therapy group, the total effective rate was 90% compared with the western medicine treatment group 81.25% (P>0.05), but the cure rate was higher than that of the western medicine group (P<0.05);The incidence of adverse reactions in the integrated therapy group was 9.68%, and the incidence rate of adverse reactions was 10.94% in the western medicine group, showing no difference between the two groups (P>0.05).Conclusion:The combination of traditional Chinese and Western medicine can improve the ovulation rate, pregnancy rate and total effective rate of treatment, and it is a safe and reliable treatment method, which is worthy of clinical application.