To observe the clinical effects of removing both phlegm and blood stasis therapy in treating connective tissue disease related interstitial lung disease (CTD-ILD); Methods:A total of 52 patients with CTD-ILD were randomly divided into treatment group and control group，with 26 cases in each group.The control group received glucocorticoid and immunosuppressive therapy，and the treatment group was added treatment with drugs of removing both phlegm and blood stasis on the basis of the above treatment for 3 months.The effective rate，he 6-minute walk distance，the arterial partial pressure of oxygen (PaO2)，forced vital capacity (FVC)，total lung capacity (TLC)，and diffusion capacity for carbon monoxide of lung (DLCO) of two groups were evaluated.Results:After treatment，the effective rates in treatment group and control group were 88.46% and 64.0% respectively，and the difference between the two groups was statistically significant (P<0.05); After the treatment，the 6-minute walk distance，PaO2，FVC，TLC and DLCO were significantly improved than that before treatment (P<0.05)，while the improvement of these indicators in the treatment group was significantly better than those of control group (P<0.05).The number of patients with adverse reactions in the control group was significantly larger than that in the treatment group (P<0.05).Conclusion:Removing both phlegm and blood stasis therapy has better clinical efficacy in treatment of CTD-ILD，which can significantly improve thepulmonary function of patients，as well as reduce the glucocorticoid and immunosuppressive drug toxicity，so it can be further applied and promoted in clinical practice.