To study the effect of lupus erythematosus I with glucocorticoid in the treatment of systemic lupus erythematosus (SLE).Methods:A total of 86 patients with SLE of yin deficiency and internal heat pattern who were admitted and treated in Affiliated Hospital of North China University of Science and Technology from January 2014 to December 2016 were selected and randomly divided into treatment group and control group，with 43 patients in each group.The patients of control group were treated by glucocorticoid therapy.The patients that glucocorticoid was invalid were treated by cyclophosphamide and the treatment continued for 3 months.Based on conventional treatment，the patients of treatment group were treated by lupus erythematosus I.The SLEDAI score，clinical curative effect，glucocorticoid，cyclophosphamide dose，the depression and anxiety of two groups were observed before treatment，after 4，8 and 12 weeks treatment.Results:After treatment，the total effective rate of the patients in the treatment group was 74.42%，which was significantly higher than 51.17% of control group，and the difference was statistically significant (P=0.027).The SLEDAI score of two groups was decreased before treatment and after 4 weeks，8 weeks treatment，and without significant difference between two groups (P=0.066，0.053); After 12 weeks treatment，the treatment group was decreased significantly than that of the control group，and the difference was statistically significant (P=0.033).The prednisone acetate average dosage and cyclophosphamide dosage of treatment group were significantly lower than that of control group (P=0.024，0.009); SDS and SAS scores of treatment group were significantly decreased，and the degree of decline was more significant than that of the control group.And the difference was statistically significant (P=0.039，0.042).Conclusion:Curative effect of lupus erythematosus I with glucocorticoid treatment of SLE is significant，which can significantly reduce the usage of glucocorticoid and cyclophosphamide and can improve the patient's state of depression，anxiety.It is more conducive to control SLE patients.