To investigate the effect of Yixin Bushen Yangyin therapy on unstable angina pectoris of coronary heart disease with heart-kidney yin deficiency and the effect on serum lipid and myocardial enzymes. Methods:A total of 105 patients with unstable angina pectoris in the first hospital of Hebei Medical University from December 2015 to December 2016 were randomly divided into observation group (n=54) and control group (n=51). The control group was treated with conventional therapy, while the observation group was treated with Yixin Bushen Yangyin therapy on the basis of the control group. The two groups were treated for 4 weeks. The therapeutic effects of the two groups were compared before and after treatment. The scores of main symptoms, blood lipid and myocardial enzyme were measured before and after treatment. Results:The total efficiency of the observation group (92.59%) was higher than the control group (70.59%) (χ2=8.569, P<0.05); the scores of palpitation, chest pain and limp aching low back and knees in observation group after the treatment were lower than that of the control group (t=21.013, 19.874, 20.275, P<0.05); CK, CK-MB and cTnI level lower than the observation group after treatment the control group (t=5.958, 17.971, 13.764, P<0.05); TC, TG and LDL-C levels after treatment in the observation group than in the control group (t=9.988, 8.834, 10.091, P<0.05), while the level of HDL-C was higher than that of the control group (t=4.755, P<0.05). Conclusion:Yixin Bushen Yangyin therapy on unstable angina pectoris with heart-kidney yin deficiency is significantly effective, and improves serum lipid and myocardial enzymes.