To establish a quality-control method for Qinggan Huayu Granule. Methods:TLC (Thin Layer Chromatography) was adopted to identify Radix Scutellariae, Radix Sophorae Flavescentis, Scutellaria barbata, zedoary etc. The main content of baicalin and matrine in the principal drug Radix Scutellariae, Radix Sophorae Flavescentis are determined by HPLC (high performance liquid chromatography) method. Results:Identification method of the TLC about Radix Scutellariae, Radix Sophorae Flavescentis, Scutellaria barbata, zedoary etc in granules was established. Under the selected conditions of HPLC, an identification method for baicalin and matrine in granules was established and the methodology complies with the requirements of Chinese Pharmacopeia. Conclusion:The identification and quantitative determination method is simple, accurate and reproducible, which can be applied to the quality control of Qinggan Huayu Granule.