To determine Tongmaisanyu gel extract and index components in different solvents' equilibrium solubility and apparent partition coefficient in different pH to explore the solvent performance of Tongmaisanyu extract. Methods:Taking the precipitation method for the determination of the solubility of the extract and equilibrium solubility of index components in different solvents as well as partition coefficient in n-octanol / water and n-octanol / buffer. Results:The equilibrium solubility of the extract in ethanol was higher at 37 ℃, and it decreased first and then increased in buffer; the solubility of salvianolic acid B and danshensu in pH buffer decreased first and then increased, and the equilibrium solubility of tanshinone ⅡA and cryptotanshinone was the highest at pH 9; the oil-water partition coefficient of salvianolic acid B and danshensu decreased with the increase of pH, and the lgP of tanshinone ⅡA and cryptotanshinone reached the maximum at pH8. Conclusion:Tongmaisanyu extract dissolves greater in alcohols, so adding an appropriate amount of ethanol in the formulation to increase the solubility may be favorable. And pH can affect the partition coefficient, so for percutaneous absorption may be promoted by adjusting the pH values.