To sort out the best method for the extraction of Shuangxinbiqiu powder. Methods:According to the pharmacological action of various ingredients in Shuangxinbiqiu powder, different extraction process were adopted, which included volatile oil extraction, aqueous extraction and alcohol extraction. The extraction technology was optimized by orthogonal test, using oil-extraction ratio as index of volatile oil extraction, using the contents of ephedrine hydrochloride and pseudoephedrine hydrochloride, dry extract yield as indexes of aqueous extraction, and using the content of baicalin, dry extract yield as indexes of alcohol extraction. Results:The optimum volatile oil extraction parameters were as follows:10 times of distilled water, decocting for 6 h. The optimum aqueous extraction parameters were as follows:8 times of distilled water, reflux extraction 3 times and 1 h each time. The optimum alcohol extraction parameters were 12, 10 and 8 times volume of 50% alcohol in turn and 1.5 h every time. Conclusion:The method complied with the rule of each drugs in prescription of Shuangxinbiqiu powder, fully performed the characteristics of the compound and ensured the pharmacological effect.