Cancer stem cells are the main cause for tumor recurrence, metastasis and multi-drug resistance.Targeting on cancer stem cells is a new way to treat cancer. However, target therapy of cancer stem cells is still in the bud now. Traditional Chinese medicine (TCM) is an important method in treating tumor in China, also proved to be effective. In the mean time, research showed that TCM has a certain effect on cancer stem cells. This paper is written to summarize the research in this field.