To observe the effect of Shiquan Dabu decoction on toxicity reducing and efficacy enhancing and immune function in colorectal cancer patients with postoperative chemotherapy.Methods:A total of 98 colorectal cancer patients admitted into our hospital from February 2015 to March 2016 were randomly divided into control group (n＝49) and observation group (n＝49).The control group took FOLFOX4 chemotherapy regimen,and the observation group took Shiquan Dabu decoction on the basis of the control group.The clinical symptoms,changes of peripheral blood T lymphocyte subsets (T cell subset,CD3+,CD4+,CD8+),toxic and side effects of two groups before and after treatment were compared,and the clinical efficacy of two groups were evaluated.Results:The total effectively rate of the observation group was 81.63%(40/49),which was higher than 61.22%(30/49) of the control group (P<0.05).Compared with pre-treatment,the CD3+,CD4+ of observation group increased and TCM symptom score decreased after treatment,and the above-mentioned indexes of observation group were better than control group (P<0.05); The incidence of leukopenia,intestinal discomfort,alopecia,nausea and vomiting in observation group was lower than control group (P<0.05).Conclusion:Shiquan Dabu decoction for colorectal cancer patients with postoperative chemotherapy can significantly increase clinical efficacy,relieve clinical symptom,reduce toxic and side effects caused by chemotherapy,strengthen immune function,and enhance body recovery,which has significance of clinical generalization.