To explore the clinical effect of invigorating blood and draining water formula combined with instrumental photodynamic therapy in preventing lower extremities fracture postoperative deep venous thrombosis (DVT). Methods:A total of 86 patients who were received lower limbs fracture operation in our hospital from February 2014 to January 2015 were divided into observation group (43 cases) and control group (43 cases) according to the random digit table. The patients in control group were treated with invigorating blood and draining water formula, while the patients in conservation group were treated with instrumental photodynamic therapy on the basis of the control group. The coagulant and fibrinolytic index (Fibrinogen, D-dimer, prothrombinogen time and activated partial prothrombinogen time) as well as hemorheology index (blood viscosity, erythrocrit and plasma viscosity) of the both group patients were compared, and DVT positive data was collected. Results:Before the experiment, the difference was not statistically significant in fibrinogen, D-dimer, prothrombinogen time and activated partial prothrombinogen time between the two groups (P>0.05). After the experiment, the level of fibrinogen and D-dimer in the observation group was significantly decreased, while the prothrombinogen time and the activated partial prothrombinogen time were slightly increased. In addition to the prothrombinogen time, the coagulant and fibrinolytic index of the two groups were significantly different, with statistically significant (P<0.05). Before the experiment, the difference was not statistically significant in blood viscosity, erythrocrit and plasma viscosity between the two groups (P>0.05). After the experiment, the blood viscosity, hematocrit and plasma viscosity of the observation group were significantly decreased. Compared with those in the control group were significant different, with statistically significant (P<0.05). There were 3 cases (6.98%) of DVT patients in the observation group and 8 cases (18.60%) of DVT patients in the control group, with statistically significant difference (P<0.05). Conclusion:The invigorating blood and draining water formula combined with instrumental photodynamic therapy in preventing lower fracture postoperative deep venous thrombosis has significant advantages, worthy of clinical promotion.