To observe the clinical efficacy of combination of traditional Chinese medicine and Western medicine and gamma globulin in the treatment of neonatal pneumonia. Methods:A total of 100 cases of neonatal pneumonia treated in our hospital from June 2015 to July 2017 were randomly divided into the control group and the observation group. The control group was given the combination treatment of traditional Chinese medicine and Western medicine. The observation group was treated with gamma globulin adjuvant therapy on the basis of the control group. The peripheral blood samples of 2 groups of neonates with pneumonia were collected before and after treatment respectively. The changes of T lymphocyte and the level of B cell antibody (including CD4+, CD8+T lymphocyte ratio, CD4+/CD8+ratio, and serum IgG, IgA, IgM levels) were detected. At the same time, the clinical efficacy of 2 groups of neonatal pneumonia was evaluated. Results:Compared with before treatment, the signs and clinical symptoms of the neonatal pneumonia in the observation group were significantly improved compared with the control group, and the clinical effective rate and cure rate were significantly improved (P<0.05). CD4+, CD8+T lymphocyte ratio, CD4+/CD8+ratio, serum IgG, IgA and IgM levels did not change significantly in the control group (P>0.05). CD4+, CD8+T lymphocyte ratio, CD4+/CD8+ratio, serum IgG, IgA and IgM levels were significantly increased in the observation group (P<0.05). Conclusion:Traditional Chinese medicine combined with intravenous injection of gamma globulin can effectively improve the clinical signs and symptoms of neonatal pneumonia, shorten the course of disease, improve the effective rate and cure rate of pneumonia. And also it can significantly enhance the immune function of the neonatal pneumonia, with significant clinical effects, which is worthy of promotion for the use of adjuvant treatment of neonatal pneumonia.