To investigate the efficacy and mechanism of treating liver-kidney yin deficiency type sjogren's syndrome with liver damage by All-Along decoction.Methods:A total of 96 patients were randomly divided into a control group (48 cases) and an observation group (48 cases).Patients in the control group were treated with Glutathione intravenous drip; while patients in the observation group received All-Along decoction treatment on the basis of control treatment.The research was aimed at evaluating the efficacy by comparing its Schirmer's test and salivary flow rate results,and monitoring the levels of TLR9,ESR,IgG,CRP,AST,ALT and TBIL.Results:The effective rate of the observation group was 91.7%,which was higher than that of the control group's 75.0% (P<0.05); The Schirmer's test and salivary flow rate of patients in both two groups after treatment went up,and the levels of TLR9,ESR,IgG,CRP,AST,ALT and TBIL went down compared after the treatment,the degree of the changes in observation group was more significant (P<0.05).Conclusion:The clinical efficacy of All-Along decoction in treating liver-kidney yin deficiency type sjogren's syndrome with liver syndrome is satisfactory as it can improve the symptoms of dry eyes and dry mouth and liver function,the mechanism may be associated with regulating the levels of TLR9,ESR,IgG and CRP.