To compare the effectiveness of compound sophora enteric capsules and glutamine enteric capsules combined with mesalazine in the treatment of ulcerative colitis. Methods:A total of 80 cases of patients with ulcerative colitis came to our hospital from January 2012 to December 2012 were randomly divided into a group A and a group B. Group A was treated with mesalazine combined with compound sophora enteric capsules, and group B was treated with Glutamine compound enteric capsules combined with mesalazine. The clinical curative effect, clinical symptoms improved time, ESR, CRP, the serum IL-8 and IL-10 levels, recurrence and adverse reactions were compared between two groups. Results:The treatment efficiency (97.5%) of group B was significantly higher than that of group A (87.5%) (P<0.05). Diarrhea time, cooling time, and symptoms and signs disappeared of group B were shorter than those of group A (P<0.05). The differences of the data about C-reactive protein, blood cell sedimentation rate between two groups had no statistically significant (P>0.05).After treatment IL-8 and IL-10 level in the two groups changed significantly, group B significantly lower than group A (P<0.05).Incidence of adverse reactions of group B was significantly lower than that of group A (P<0.05). Conclusion:Glutamine compound enteric capsules combined with mesalazine can significantly improve clinical outcomes and clinical symptoms, and decrease adverse reaction rate in ulcerative colitis patients, which was worthy of promotion.