To observe the treatment effect of Ji Desheng She tablets combined with ultrasound-guided thoracic paravertebral nerve block on herpes zoster. Methods:A total of 100 patients with herpes zoster were randomly divided into observation group and control group. The observation group was treated with Ji Desheng She tablets combined with ultrasound-guided thoracic paravertebral nerve block, and the control group was treated with peneiclovir cream. The total effective rate and visual analogue scale (VAS) the days for blister, scab, heal and the neuralgia accident rate were observed. Results:The efficiency of the observation group was higher than control group (P<0.05). After treated by 1, 2, 4 and 8 weeks, VAS score of both groups were gradually decreased, and the observation group was significantly better than the control group (P<0.05). The days for blister, scab, heal and the neuralgia accident rate of the observation group were shorter than control group (P<0.05). Conclusion:Ji Desheng She tablets combined with ultrasound-guided thoracic paravertebral nerve block in treating herpes zoster has significant effects.