To explore the curative effect of reduning injection combined with zinc gluconate in the treatment of infantile diarrhea and its effect on cellular immunity. Methods:A total of 102 cases of patients with infantile diarrhea in our hospital were selected and randomly divided into the treatment group (n＝51) and the control group (n＝51). The control group was treated with montmorillonite powder, and treatment group was treated with reduning injection combined with zinc gluconate. Clinical curative effect, clinical performance, immune index of 2 groups were compared. Results:The total clinical effective rate of the control group was 76.47%, which was significantly lower than 90.20% of the treatment group (P<0.05); there was no significant difference in stool frequency between 2 groups (P>0.05). The stool recovery time of the control group was longer than the treatment group (P<0.05); Compared with that before treatment, red cell C3b receptor rosette (RC3bRR), the red blood cell immune complex rosette (RICR), rosette forming enhancement rate (RFER) of 2 groups after treatment were significantly increased, and rosette forming inhibitor rate (RFIR) was significantly decreased (P<0.05 or P<0.01) with significant difference between 2 groups (P<0.05 or P<0.01); Compared with that before treatment, the ratio of CD3+, CD4+ and CD4+/CD8+ of 2 groups after treatment were significantly increased (P<0.05 or P<0.01), and the treatment group was higher than the control group (P<0.05 or P<0.01). There was no significant difference of CD8+ between 2 groups before and after treatment (P>0.05); Compared with that before treatment, the levels of serum immunoglobulin A (IgA), immunoglobulin G (IgG), fecal secretory IgA (sIgA) of 2 groups after treatment were significantly increased (P<0.01), and the treatment group was higher than the control group (P<0.05 or P<0.01). Conclusion:Reduning injection combined with zinc gluconate in the treatment of infantile diarrhea can improve the clinical symptom and immune function, with remarkable curative effect, which is worthy of promotion.