To pursue the clinical and echocardiographic study of modified Wumei Decoction in the treatment of insomnia.Methods:Sixty cases of insomnia were divided into an observation group and a control group,each 30 cases.The observation group's patients took modified Wumei decoction,the control group estazolam.The course of the two groups were all 14 d.The therapeutic effect of the two groups,PSQI score,cerebral artery ultrasound imaging and the main symptom score changes before and after treatment were compared,as well as adverse reactions.Results:The total effective rate of the observation group (93.33%) was higher than that of the control group (66.67%) (P<0.05); TCM symptoms total effective rate of the observation group (96.67%) was higher than that of the control group (63.33%) (P<0.05); patients in the observation group after treatment had lower PSQI score (P<0.05); after treatment,middle cerebral artery,basilar artery and vertebral artery Vs,Vm of patients in the observation group were higher than those of the control group,while RI was lower (P<0.05); after treatment,patients' core of tiredness,palpitations,being easily surprised,sleepiness in the morning,over dreaming,being easy to wake up,sleep difficulties in the observation group were lower than those of the control group (P<0.05); the two groups showed no obvious adverse reactions.Conclusion:The modified Wumei decoction can improve the cerebral blood flow state of patients in the clinical treatment of insomnia and is worthy of study.