To analyze the curative effects of Weikuiling decoction combined with acupuncture and moxibustion on peptic ulcer and influence on the levels of serum immune function protein and serum inflammatory factors. Methods:A total of 70 patients with peptic ulcer in our hospital from May 2015 to June 2016 were selected and randomly divided into 2 groups according to the order of treatment, with 35 cases in each group. The control group was given Weikuiling decoction, while the observation group was treated with acupuncture on the basis of the control group. The clinical efficacy, TCM syndrome score, immunoglobulin levels, serum levels of inflammatory factors of 2 groups before and after treatment were measured. Results:The total efficiency of the observation group was 94.29% and 71.43% in the control group, The difference between the 2 groups was statistically significant (P<0.05); TCM symptom scores of fatigue, epigastric pain, belching, acid regurgitation, anorexia and loose stools after treatment in observation group were significantly lower than the control group (P<0.05); the levels of immunoglobulin IgG, IgA, IgM in the observation group after treatment were significantly higher than that of the control group (P<0.05); The levels of IL-6, TNF-alpha, TGF-beta 1 after treatment in observation group were significantly lower than the control group. Conclusion:Acupuncture combined with Weikuiling decoction has good effects in treating peptic ulcer, and can effectively improve the levels of immune function protein and serum inflammatory factors in patients with peptic ulcer.