To explore the clinical efficacy of radiofrequency ablation combined with Tongluo Yishen Fang in the treatment of Lumbar disc herniation (LDH) and its effects on the levels of IL-1β, MMP-3 and TNF-α. Methods:A total of 144 cases LDH patients who were admitted and treated in our hospital from June 2012 to May 2016 were selected and randomly divided into control group and observation group, with 72 cases in each group. The Control group was treated with radiofrequency ablation, while the observation group was treated with Tongluo Yishen Fang based on the control group. 2 groups were treated continuously for 4 weeks. The total efficacy rate of 2 groups was recorded, and the serum IL-1β, MMP-3, TNF-α levels before and 1, 3 months after treatment in 2 groups were detected. The pain and anxiety of 2 groups were compared. The lumbar function and life quality before and after treatment were evaluated and compared. Results:The clinical total effective rate of observation group was 93.06% (67/72), which was higher than that 76.39% (55/72) of control group (P<0.05); Compared with before treatment, the levels of serum IL-1β, MMP-3, TNF-α levels of 2 groups decreased significantly (P<0.01). The VAS and SAS scores from 1 to 3 months decreased significantly, and which in observation group were lower than that in control group (P<0.01); Compared with before treatment, the ODI of 2 groups 3 months after treatment decreased significantly, and there was significant difference between 2 groups (P<0.01); while the lumbar function score and SF-36 score increased significantly, and there was significant difference between 2 groups (P<0.01). Conclusion:The clinical efficacy of radiofrequency ablation combined with Tongluo Yishen Fang is significant in the treatment of LDH, which can inhibit inflammatory response and Lumbar disc degeneration, promote the lumbar functional recovery, and can relief the pain and patients' anxiety effectively, as well as improve the patients quality of life with favorable prognosis.