To study the effects of Shoutai Pill and Siwu Decoction combined with progesterone tablet on the immune factors of patients with unexplained recurrent spontaneous abortion. Methods:A total of 84 cases of unexplained recurrent abortion patients who were admitted in our hospital from February 2015 to February 2016 were chosen as the research object, and divided into observation group and control group according to the random number table. The control group was treated with progesterone tablets, and the observation group were treated with Shoutai Pill and Siwu Decoction on the basis of the observation group. The clinical curative effect and pregnancy rate of two groups were observed, and the level of inflammatory factors was determined. TCM symptom score of 2 groups were compared. Results:In the observation group, 21 cases were cured, and 19 cases were effective with the total efficiency of 95.24%. 35 cases were successful pregnancy with repeated abortion rate of 93.02%; In the control group, 10 cases were cured and 17 cases were effective with total efficiency of 64.29%. 12 cases were successful pregnancy with repeated abortion rate of 71.43%. The differences between 2 groups were statistically significant (P<0.05). After treatment, TCM symptoms score was 5.86±1.24 in observation group and 8.67±1.48 in control group. The difference was statistically significant (P<0.05). After treatment, levels of D dimer, IL-10 and TNF-a of 2 groups were changed compared with before treatment; the decrease of D-dimer and TNF-levels in observation group was more significant, and the level of IL-10 increased significantly. The difference between 2 groups was statistically significant (P<0.05). Conclusion:Shoutai Pill and Siwu Decoction combined with progesterone tablets in the treatment of unexplained recurrent abortion is safe and effective, which can significantly improve the cell immune factor level and increase the success rate of pregnancy.