To explore the curative effect of Jianpi Shengxue tablet in the treatment of gestational iron deficiency anemia, and to evaluate the clinical curative effect and safety. Methods:A total of 180 patients with gestational iron deficiency anemia who were treated in our hospital from August 2014 to January 2016, were randomly divided into control group and observation group with 90 cases in each group. The control group was given Proteinsuccinylate Oral Solution, one drink one time, 2 times/d; The observation group received Jianpi Shengxue tablet, three tablets one time, 3 times/d. The treatment last for continuous three months. The clinical curative effects of the two groups were evaluated. Red blood cell (RBC), hemoglobin (Hb), hematocrit (HCT), Mean Corpuscular Volume (MCV), serum ferritin (SF), transferrin saturation (TSAT) and serum iron (SI) before treatment and after treatment were assessed and the adverse reactions were recorded. Results:After 3 months' treatment, the biochemical indicators such as RBC, Hb, HCT， MCV and Iron metabolism indexes such as SF, TSAT and SI levels in 2 groups were higher than that of pre-therapy (P<0.05), while the observation group took effect faster (P<0.05). The indexes were better than the control group in 1, 2 and 3 months after treatment (P<0.05); After 3 months, the symptom of anemia in observation group was significantly improved and the total effective rate was higher (P<0.05); The adverse reactions of the observation group had no significant difference compared with the control group (P<0.05). Conclusion:There is a significant curative effect of Jianpi Shengxue tablet in the treatment of gestational iron deficiency anemia. It can improve anemia clinical symptoms with safety, which is worthy of clinical application.