By listing proven cases, in which Shaoyao Gancao Decoction was applied to treat spleen and stomach diseases such as esophageal hiatus hernia, stomach mucous membrane prolapse, borborygmus, regurgitation and salivating of Parkinson's disease, this paper discussed the clinical feasibility of treatment based on disease differentiation based on modern medicine pathological mechanism and modern pharmacological results. And this paper also pointed out that treatment on disease differentiation was a supplement to syndrome differentiation, and the combination could improve the clinical efficacy.