To study the analgesic effect of Qinqi Rheumatism Capsule and its effect on immune function through various animal models.Methods:The analgesic effects of Qinqi Rheumatism Capsule were investigated on animal models by acetic acid twisting method,the method of flicking tail,toes pain tenderness and tail pain tenderness test; The influence of Qinqi Rheumatism Capsule on the immune function in mice was investigated by mouse immune organ' weight test,serum hemolysin antibody test and dinitrofluorobenzene (DNFB)-induced delayed-type hypersensitivity (DTH) model.Results:Qinqi Rheumatism Capsule significantly reduced the number of acetic acid-induced writhing,improved the thermal pain threshold in mice,and alleviated the pain degree in toes and tail pain tenderness,indicating that the analgesic effect of Qinqi Rheumatism Capsule; In addition,it could also inhibit the production of hemolysin antibody and delayed-type hypersensitivity induced by DNFB,suggesting the inhibitory effect of Qinqi Rheumatism Capsule on innate immune and cellular immune function.Conclusion:Qinqi Rheumatism Capsule has obvious analgesic and inhibitory effect on immune function.This study provides a pharmacological basis for Qinqi Rheumatism Capsule's clinical treatment of rheumatoid arthritis.