To investigate the protective effects of Maishu on acute liver injury and lipid-lowering. Methods:Hyperlipidemia model was induced by high-fat diet. Male SD rats were randomly divided into control group, model group, positive treatment group, Maishu high dose group, middle dose group and low dose group; Except control group, other groups were feeded with high-fat diet and drugs. At the end of 4 weeks, the levels of serum TC, TG, LDL-C, HDL-C, SOD and MDA were determined. Another 60 rats were randomly divided into the control group, model group, tiopronin group, Maishu high dose group, middle dose group and low dose group. The model of alcoholic liver damage in mice was induced by intragastic administration of alcohol. Each group was given continuously by gavage 28 days. The serum levels of ALT, AST and TG were determined. The content of VLDL was determined by ELISA. Histopathological changes of the liver were observed by HE staining. Results:Comparing with the model group, Maishu high dose, middle dose and low dose had little or even no influence on mice's weight, and had no adverse effects on the levels of TC and HDL-C of hyperlipidemic rats. But it can significantly decrease the levels of TG ang LDL-C, as well as increase SOD and reduce the MDA content (P<0.05, P<0.01). It could significantly reduce ALT, AST, TG and VLDL on acute alcoholic liver injure in rats. Mashu high dose can improve hepatocyte-steatosis (P<0.05, P<0.01). Conclusion:Maishu is effective on blood-lipid regulation of the hyperlipidemia model rats and it has protective effects on ethanol-induced acute hepatic injury in mice.