To observe the short-term and long-term efficacy and laboratory indicators of small needle knife, acupuncture combined with electro-acupuncture in the treatment of cervical vertigo. Methods:A total of 92 patients with cervical vertigo were selected and divided into observation group and control group according to the random number table, with 46 cases in each group. The observation group received small needle knife, acupuncture combined with electro-acupuncture treatment, and the control group was treated combined with small needle knife and acupuncture. The vertigo score, serum lysophosphatidic acid (LPA), the systolic peak velocity (Vs) of basal artery and vertebral artery before and after treatment, the total effective rate and follow-up of 1 year recurrence rate were compared between 2 groups. Results:The levels of vertigo and serum LPA in the observation group were lower than those before treatment and those in control group (P<0.05). The peak systolic velocity of the left vertebral artery, the right vertebral artery and the basilar artery in the observation group were higher than those before treatment and those in control group (P<0.05). The total effective rate was 93.48% in the observation group, which was higher than 78.26% in the control group (P<0.05). The recurrence rate was 4.34% in the observation group, which was lower than 17.39% in control group (P<0.05). Conclusion:Small needle knife, acupuncture combined with electro-acupuncture treatment of cervical vertigo can effectively improve the patient's vertigo score, reduce serum LPA levels, improve vertebral-basilar artery hemodynamics, and can reduce recurrence with good middle-term and long-term efficacy.