To explore the effects of acupuncture combined with probucol on recovery of nerve function and inflammatory factors of patients with ischemic cerebrovascular disease with carotid plaque. Methods:A total of 125 cases of patients with ischemic cerebrovascular disease with carotid plaque from April 2013 to April 2017 were selected and randomly divided into observation group (n＝63) and control group (n＝62). The control group was treated with probucol, and the observation group was treated with acupuncture on the basis of control group. Both groups were treated for 50 days. The clinical efficacy of 2 groups was compared. The plaque condition of 2 groups before and after treatment was detected. The recovery of nerve function and the levels of inflammatory factors of 2 groups before and after treatment were compared. Results:The total effective rate of observation group reached up to 96.83% after treatment, which was higher than that 85.48% of control group (P<0.01); Compared with before treatment, the IMT, plaque area, number of plaques of 2 groups decreased after treatment, and observation group was lower than control group (P<0.05 or P<0.01); Compared with before treatment, the levels of serum HbA1c, plasma Hcy, NHISS scores and the levels of serum hs-CRP, IL-6, IL-18 of 2 groups decreased after treatment, and observation group was lower than control group (P<0.01). Conclusion:Acupuncture combined with probucol in the treatment of ischemic cerebrovascular disease with carotid plaque can inhibit the development of plaque, reduce the degree of neurological deficits and the levels of serum inflammatory factor, and the clinical efficacy is remarkable.