To evaluate the quality difference of precise powder decoction pieces (PPDP) of Citri Retilulatae Pericarpium (CRP) and traditional commercial crude slices.Methods:Different specifications of PPDP were prepared,their dry extract contents were compared with those of commercial slices.Three batches of commercial slices were collected,and the content uniformity,fingerprint and similarity were evaluated before and after mixing and preparation by HPLC-DAD and DNA sequence alignment.Results:Paste rate of PPDP was slightly higher than that of the traditional commercial slices,among which paste rate of 5-10 mesh were the highest.The dissolution rate of hesperidin of PPDP was higher than that of traditional commercial slices.RSD of inter-assay dissolution of commercial slices was 18.93%,which could be reduced to 6.28 % after being mixed and prepared into PPDP.Conclusion:PPDP and traditional commercial slices of CRP shared consistent properties,while PPDP could apparently improve the extraction rate,the dissolution rate and the quality uniformity,which demonstrates boiled powder of CRP is more suitable in clinical practice.