This study aimed to evaluate the composition dissolution and quality uniformity of precise powder decoction pieces (PPDP) of Aurantii Fructus (AF),compared with the traditional commercial slices.Chemical fingerprint methods and DNA molecular identification technology based on internal transcribed spacer 2 (ITS2) were applied.Methods:Different specifications of PPDP were prepared,their dry extract contents were compared with those of commercial slices.Three batches of commercial slices were collected,and the content uniformity,fingerprint and similarity evaluation before and after the mixing and pulverization were analyzed by HPLC-DAD and DNA sequence alignment.Results:Paste rate of PPDP were slightly higher than that of the traditional commercial slices.The dissolution of naringin of PPDP was higher than that of traditional commercial slices.RSD of inter-assay dissolutions of naringin and neohesperidin of commercial slices were 9.71% and 24.71% respectively,which could be reduced to 4.73% and 4.94% after mixing and preparing into PPDP.Finger print image shows there were high similarity between decoction and slices.Conclusion:PPDP and traditional commercial slices of AF shared consistent properties.PPDP apparently improved the extraction rate,the dissolution rate and quality uniformity,and it is recommended to be used in clinical practice.