To study the correlation between oxidative stress and excess heat “shanghuo” through observing the changes of blood lipid peroxidation index (MDA, ROS) and antioxidant indexes (GSH, T-AOC,SOD) in the population of excess heat “shanghuo”. Methods:Excess heat “shanghuo” and normal population samples were collected, and the levels of MDA, GSH, SOD and T-AOC in plasma and ROS in peripheral blood leukocytes were detected and compared respectively. Results:The levels of MDA, GSH, SOD and T-AOC in the blood plasma of excess heat “shanghuo” were higher than those in the normal group (P<0.05), and the levels of ROS in leukocytes decreased significantly (P<0.01). Conclusion:The excess oxidation index (MDA) and antioxidant index (GSH, SOD, T-AOC) were all increased in excess heat “shanghuo” people, and the levels of ROS in leukocytes decreased significantly, indicating that excess heat “shanghuo” is closely related to oxidative stress; the organism is in a level state of oxidation and antioxidation, but the oxidation and antioxidant levels are in balance.