To investigate the clinical efficacy and Influence of hs-CRP,PCT, IL-2 and IL-10 levels for treating acute pelvic inflammatory disease with fule granules.Methods:One hundred and twelve patients were randomly divided into a control group of 56 cases and an observation group of 56 cases.Patients in the control group were treated with indications for injection intravenous drip;while patients in the observation group were treated with fule granules,four weeks for treatment.The research was focus on comparing the effectiveness,evaluating its syndrome integral, recording the disappear time of main symptoms and testing the levels change of inflammatory factors.Results:The efficiency for patients in the observation group was 91.1%,which was higher than that of the control group 75.0%,difference was very remarkable(P<0.05);The TCM syndrome integrals for patients in the observation group were lower than that of the control group,difference was very remarkable(P<0.05);The disappear time of main symptoms for patients in the observation group were less than that of the control group, difference was very remarkable(P<0.05);The levels of hs-CRP and PCT for patients in the observation group were lower than that of the control group after treatment(P<0.05);while the level of IL-2 and IL-10 for patients in the observation group was higher than that of the control group after treatment(P<0.05).Conclusion:The therapy has good effect,it can improve the patients' clinical symptoms and shorten the duration of symptoms.The mechanism may be associated with the regulation of cytokines levels in the blood to reduce the body's inflammatory response in patients with acute pelvic inflammatory disease,is worthy of further research and development.