To investigate the curative effects of Yinxingdamo and Xingnaojing on patients with cerebral hemorrhage, and effects on peripheral blood S100B and neuropeptide Y (NPY). Methods:A total of 80 cases of patients with cerebral hemorrhage admitted in our hospital from January 2015 to June 2017 were selected and divided into two groups according to the random number table method. The control group was given Xingnaojing treatment, while the observation group was given Yinxingdamo combined with Xingnaojing treatment. The brain edema absorption effect, NIHSS score, peripheral blood S100B and NPY levels before and after the treatment of the two groups were recorded and compared, and the safety of medication of the two groups was evaluated. Results:After treatment for 14 d, the total effective rate of cerebral hematoma absorption in observation group was 90%, which was significantly higher than that in control group (72.5%) (P<0.01). NIHSS score in the two groups were all significantly lower than before treatment (P<0.01), and the improvement effect in observation group was more significant than that in control group (P<0.01). Compared with that before treatment, the levels of S100B and NPY in the two groups were all significantly decreased after 14 d treatment (P<0.01), and the improvement effect in observation group was more significant than that in control group (P<0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion:Yinxingdamo combined with Xingnaojing displays a remarkable synergistic effect in the treatment of hemorrhagic encephalopathy with high safety, so it is worthy of promotion.