To observe the clinical effect of Jiaweidangguibuxue Decoction for treating kidney deficiency and blood stasis of IgA nephropathy and its influence on the immune system of patients, and to analyze the prognosis and discuss the related mechanism.Methods:A total of 126 patients with kidney deficiency and blood stasis type IgA nephropathy in our hospital from January 2010 to January 2012 were randomly selected.The patients were divided into the control group and the treatment group according to random number table method.The control group was treated with losartan 50 mg qd on the basis of basic treatment.The treatment group was treated with Jiaweidangguibuxue Decoction on the basis of the control group.24 hours urine protein, urine red blood cell, serum IgA and T lymphocyte subgroup CD4+/ CD8+ value were detected before and after treatment respectively.And renal biopsy was performed.The glomerular pathological scores were evaluated.The numerical statistical difference was compared, and the clinical curative effect and prognosis of two groups was analyzed.Results:After treatment, 24 hours urine protein, urine red blood cell count, serum creatinine of two groups after treatment were significantly lower than that before treatment (P<0.05).CD4+/ CD8+ and serum IgA value of two groups were decreased (P<0.05), and the treatment group was better than the control group (P<0.05).The clinical efficacy of the two groups was compared.The total effective rate (93.44%) of treatment group was better than the control group (83.33%), and in the follow-up analysis of the prognosis of the two groups in 1 year, kidney survival rate in one year had no statistically significant differences (P>0.05), and 3, 5 years survival rate of the patients in treatment group was significantly better than the control group (P<0.05).Conclusion:Jiaweidangguibuxue Decoction can increase the clinical effect of treating kidney deficiency and blood stasis type IgA nephropathy, improve the immune function of patients with IgA nephropathy, improve the survival rate and improve the prognosis.