To study clinical study and prognosis analysis of Fuzheng anti tumor prescription combined with radiofrequency ablation in treatment of elderly patients with advanced non-small cell lung cancer.Methods:A total of 136 patients with NSCLC in our hospital from February 2011 to May 2013 were randomly divided into the observation group (n＝68 cases) and the control group (n＝68 cases).The control group was treated with radiofrequency catheter ablation (RFA), and the observation group was treated in combination with “Fuzheng anti tumor prescription” on the basis of above treatment.The two groups were treated for 2 months.The short-term efficacy, survival rate, quality of life (QOL) and physical condition (PS) score of two groups were evaluated, and the incidence of adverse reactions in the two groups was observed during the treatment period of 3 years.Results:The remission rate of the control group was 60.3%, and the remission rate of the observation group was 88.2%.The difference between the two groups was statistically significant (P<0.05).2 weeks after operation, there was no significant difference between the two groups in QOL and PS scores (P>0.05).After 1 months and 3 months, the improvement of QOL and PS scores in the observation group was significantly better than that in the control group, and the difference was statistically significant (P<0.05).After treatment, the scores of cough, shortness of breath, lassitude, appetite, insomnia and other clinical symptoms in the observation group were significantly lower than those in the control group (P<0.05).The incidence of chest pain, pleural effusion, hemoptysis, fever and digestive tract adverse reactions in the observation group was significantly lower than that in the control group (P<0.05).The 1 year survival rate of the observation group was significantly higher than that of the control group, and the difference was significant (P<0.05).There was no significant difference in the 2 and 3 year survival rates between the two groups (P>0.05).Conclusion:The short-term efficacy of Fuzheng anti tumor prescription combined with RFA in the treatment of advanced NSCLC in the elderly is very significant, can improve the patient's physical condition and clinical symptoms, and improve the quality of life of patients with small trauma and high safety.Long-term treatment has obvious advantages in prolonging survival rate, and it is worthy of clinical promotion.