To observe the curative effect of Shenqi Shoutai prescription combined with euthyrox in treatment of the early phase threatened abortion with subclinical hypothyroidism and its effect on cytokines of HMGB1 and RAGE in peripheral blood.Methods:A total of 78 cases of patients with early threatened abortion with subclinical hypothyroidism admitted into our hospital from March 2015 to March 2016 meeting the requirement of the research were selected.Then divided into study group and control group with 39 cases in each group.The study group was given Shenqi Shoutai prescription combined with euthyrox for treatment; and the control group was given progesterone Injection and euthyrox for treatment.The level changes of serum β-human chorionic gonadotropin,estradiol,progesterone,TSH and peripheral hematoma HMGB1 and RAGE for patients in two groups were compared.Results:After treatment,the positive rate of high mobility group protein B1 (high mobility group box 1 protein,HMGB1),advanced glycation end products (receptor for advanced glycationend product receptor,RAGE) was superior to those of the control group and the comparison was of statistical significance (P<0.05).The total efficiency of the study group was 84.62%,which was higher than the 69.23% in the control group.The difference was of statistical significance (P<0.05).After treatment,the index of serum beta human chorionic gonadotropin (beta-Human chorionic gonadotrophin,P-HCG),estradiol (Estradiol2,E2),progesterone (Progesterone,P) and thyroid stimulating hormone (Thyroid stimulating,hormone,TSH) was better than that of the control group.The comparison was of statistical significance (P<0.05).Conclusion:Shenqi Shoutai Prescription combined with euthyrox in the treatment of early threatened abortion with subclinical hypothyroidism has significant clinical effect.It can help patients to improve clinical symptoms,maintain patients' corpus luteum,recover to normal gestation level,reduce thyroid hormone secretion,improve thyroid function,reduce the cytokines indexes of HMGB1 and RAGE in peripheral blood,help the inflammatory medium secretion in the body,enhance immune capacity,fully regulate the body fluid and cellular immunity,and promote the relative balance of body immune state.