To observe the influence of Yishen Huoxue Xiaozheng Fang on endocrine function and hemorheology of uterine fibroids kidney deficiency and blood stasis patients. Methods:A retrospective analysis of 40 cases of uterine fibroids kidney deficiency and blood stasis patients from June 2015 to June 2016 in our hospital was conducted. The patients were divided into the observation group and the control group according to the random number table method, with 20 cases in each group. The control group was given mifepristone tablets, and the observation group added to Yishen Huoxue Xiaozheng Fang on the basis of control group. Both groups were treated for 3 months continuously. The tumor volume, uterine volume, reproductive endocrine hormones (Progesterone (P), estradiol (E2), luteinizing hormone (LH), follicle growth hormone (FSH) and serum prolactin (PRL)) and the improve situation of hemorheology (whole blood viscosity, high shear and low shear whole blood viscosity, plasma viscosity, hematocrit, erythrocyte aggregation index, erythrocyte sedimentation rate and fibrinogen) of 2 groups before and after treatment were compared, and the clinical efficacy of 2 groups was statisticsed. Results:The total effective rate of observation group (90.0%) was significantly higher than control group (80.0%) (P<0.05). The volume of uterus and myoma of 2 groups had no significant difference before treatment (P>0.05), and the volume of uterus and volume of myoma of 2 groups reduced than before treatment (P<0.05). The degree of reduction of observation group was more significant than that of the control group, and there was significant difference between 2 groups (P<0.05); the reproductive endocrine hormones levels of 2 groups had no significant difference before treatment (P>0.05), and the reproductive endocrine hormones levels of 2 groups decreased significantly after treatment. The degree of reduction of observation group was more significant than that of the control group, and there was significant difference between 2 groups (P<0.05); the hemorheology levels of 2 groups had no significant difference before treatment (P>0.05), and the whole blood viscosity, high shear and low shear whole blood viscosity, plasma viscosity, erythrocyte aggregation index, erythrocyte sedimentation rate and fibrinogen levels of 2 groups decreased significantly after treatment. The hematocrit increased significantly, and the improvement degree of the observation group was more significant than that of the control group. There was significant difference between 2 groups (P<0.05). Conclusion:Yishen Huoxue Xiaozheng Fang can effectively improve the endocrine function and hemorheology levels of patients, reduce the volume of uterus and myoma, enhance the clinical efficiency, which is worthy of clinical application.