To explore the improvement effects of Liuyu Decoction on olanzapine-induced metabolism syndrome of schizophrenic patients. Methods:A total of 120 cases schizophrenic with metabolic syndrome patients were selected and randomly divided into observation group (n＝60) and control group (n＝60). The observation group was treated with Liuyu Decoction and olanzapine, and the control group was treated with olanzapine. Both groups were treated for 12 weeks. The clinical efficacy of 2 groups was compared, and the changes of the glucose and lipid metabolism, body mass index, blood press of 2 groups before and after treatment were compared; The improvement of psychiatric symptoms of 2 groups was compared; The adverse reactions of 2 groups during the treatment were recorded. Results:The total effective rate of observation group (93.33%) was higher than control group (71.67%) (P<0.01); Compared with before treatment, the levels of serum FPG, HbAlc, TG and BMI of observation group decreased after treatment, and which were lower than control group (P<0.05 or P<0.01); The serum HDL of observation group after treatment increased than that before treatment, and which was higher than control group (P<0.01). The DBP and SBP of observation group after treatment decreased than that before treatment, and which were lower than control group (P<0.05 or P<0.01). The scores of PANSS and TESS of 2 groups after treatment decreased than that before treatment, and observation group was lower than control group (P<0.05 or P<0.01). Conclusion:Liuyu Decoction can effectively improve the glucose and lipid metabolism of olanzapine-induced metabolism syndrome of schizophrenic patients, effectively regulate the blood press of patients and improve the psychiatric symptoms with good safety.