To investigate the influence of self-made Qubi Decoction and Simiao powder on immune indexes in patients with dampness heat type rheumatoid arthritis. Methods:A total of 70 cases with the damp heat syndrome of rheumatoid arthritis in our hospital from May 2013 to May 2016were selected and randomly divided into 2 groups, of which the control group of 35 cases were treated with western medicine treatment and the study groups of 35 cases were treated with Qubi Decoction and Simiao powder. After the treatment, the two groups were compared in terms of serum immune index, joint symptoms and recovery effect. Results:After the treatment, IgG, IgA, IgM, RF and ESR of the study group were significantly lower than the normal group, and the difference was statistically significant (P<0.05); C3 and C4 of the study group were significantly higher than the normal group, and the difference was statistically significant (P<0.05); joint pain, joint tenderness, joint the swelling numbers of the study group were significantly lower than the conventional group, and the difference was statistically significant (P<0.05); the total effective rate of the treatment group was 94.29%, significantly higher than 82.86% of conventional group, and the difference was statistically significant (P<0.05). Conclusion:The self-made Qubi decoction combined with Simiao powder can effectively improve the serum immune indexes of patients with damp heat type rheumatoid arthritis, and the curative effect is remarkable, without side effects.