To observe the impact of Liuwei Dihuang Pills on the quality of life of the patients with menopausal syndrome, and to explore the intervention effect on neuroendocrine immune network of the body. Methods:A total of 80 patients with climacteric syndrome in our hospital during January 2011 to January 2016 were included and randomly divided into the control group and the observation group, with 40 cases in each group. The two groups of patients all had oral administration of estradiol/norethindrone acetate tablets, and the observation group took Liuwei Dihuang Pills on the basis of the above drug therapy. Both groups were treated for three months as a course of treatment. After treatment, the clinical curative effect, life quality scores, the concentration of NE (norepinephrine), DA (dopamine), 5-HT (serotonin), 5-HIAA (5-hydroxy indole acetic acid), and the percentage changes of Th17 cell of two groups were compared. Results:1) The TCM syndrome scores of two groups were decreased after treatment (P<0.05). The decrease trend of observation group was significantly significant than that of the control group (P<0.05).2) After treatment, SF-36 dimensions were increased in the two groups than before treatment (P<0.05), and the increase scores of the observation group was significantly larger than the control group (P<0.05); 3) The concentration of DA, 5-HT, 5-HIAA of the two groups after treatment significantly decreased than before treatment (P<0.05), and the NE content rebounded significantly (P<0.05). The improvement of the above-mentioned indexes in the observation group was more significant than the control group (P<0.05). Conclusion:Liuwei Dihuang Pills can significantly improve the quality of life of patients with menopausal syndrome, and the mechanism of action may realized by adjusting the neuroendocrine immune of the patients.