To investigate the clinical efficacy of treating osteoarthritis patients with fufangxuanju capsule combined ozone therapy.Methods:One hundred cases were randomly divided into a control group of 50 cases and an observation group of 50 cases.Patients in the control group were treated with ozone therapy; while patients in the observation group were treated with fufangxuanju capsule combined ozone therapy.The paper was aimed at comparing the effectiveness,evaluating the knee joint pain, knee function and joint stiffness degree of change, and testing the change levels of TNF-α, IL-1β, BGP and OPG.Results:The efficiency of the observation group was 92.0%,which was higher than that of the control group 78.0%(P<0.05);the VAS and WOMAC scores of the two groups after treatment went down compared with before treatment,while the Lyshom scores increased compared with before treatment, and the change degree of observation group was more apparent(P<0.05);the TNF-α and IL-1β levels of the two groups after treatment went down compared with before treatment,while the OPG and BGP levels increased compared with before treatment,and the change degree of observation group was more apparent(P<0.05).Conclusion:Treating osteoarthritis patients with fufangxuanju capsule combined ozone therapy can significantly alleviate the symptom such as patients with osteoarthritis joint pain,stiffness,and improve the ability of joint movement.The mechanism may be associated with lowing TNF-α,IL-1β,OPG and BGP levels to reduce inflammation injury and regulate bone metabolism.