To evaluate the efficacy and safety of early enteral nutrition combined with Chaiqin Chengqi decoction in the treatment of severe acute pancreatitis. Methods:From January 2013 to January 2014, a total of 64 patients with severe acute pancreatitis in the department of integrated TCM & western medicine, West China Hospital of Sichuan University were randomly divided into observation group and control group, with 32 cases in each group. All patients in two groups were received standard western medicine treatment. Among them, the observation group was given enteral nutrition combined with Chaiqin Chengqi decoction, and the control group was given parenteral nutrition. The observation indexes included the serum amylase, the serum CRP, TNF-α, the TCM symptom score, the modified Marshall score, the CT score, the incidence of the complication, the hospitalization time and the treatment costs. Results:There was no significant difference in baseline between the two groups (P>0.05), which was comparable. All of the 64 patients had completed the trial according to the protocol. After treatment, the serum amylase and the serum CRP, TNF-alpha, the TCM symptom score, the modified Marshall score, the CT score in the observation group were significantly better than those in the control group (P<0.05). The complication rate of multiple organ dysfunction and peripancreatic abscess in the observation group was lower than that in the control group (P<0.05), while the incidence of pseudocyst was the same in the two groups (P<0.05). The hospitalization time of the observation group was shorter than that of the control group (P<0.05), and the treatment cost was lower than that of the control group (P<0.05). No drug-related adverse reactions were observed in the two groups. Conclusion:There is a good clinical curative effect and safety，short hospitalization time, and low treatment cost in the treatment of SAP by the use of early enteral nutrition combined with Chaiqin Chengqi Decoction, which is worthy of promotion and application.