To explore the clinical efficacy of Qingrelishi Quyu method in the treatment of chronic prostatitis patients and the effect on local immune function. Methods:A total of 228 chronic prostatitis patients who were treated in our hospital from January 2017 to June 2017 were selected and randomly divided into control group (n＝114) and experiment group (n＝114). Control group were treated with conventional western medicine treatment, and experiment group were treated with Qingrelishi Quyu decoction on the basis of control group. 14 d were 1 treatment course, and 2 groups were treated for 3 courses continuously. The clinical efficacy of 2 groups was counted and the improvement of clinical symptoms before and after treatment in 2 groups was evaluated. Additionally, the WBC and immune indexes of prostatic fluid in 2 groups before and after treatment were detected and compared. Results:The total effective rate of experiment group reached up to 93.86% after treatment, which was higher than that 73.68% of control group (P<0.01); Compared with the score before treatment, the IIEF score of 2 groups increased significantly after treatment, and experiment group was higher than control group (P<0.01); the NIH-CPSI and QOL scores of 2 group decreased significantly after treatment, and experiment group was lower than control group (P<0.01); Compared with the one before treatment, the WBC of prostatic fluid in 2 groups decreased significantly after treatment (P<0.05 or P<0.01), and experiment group was lower than control goup (P<0.05); Compared with the level before treatment, the SIgA and IgG levels of prostatic fluid in experiment group decreased significantly after treatment, and which were lower than that of control group (P<0.01). Conclusion:Qingrelishi Quyu method can improve the clinical symptoms of chronic prostatitis patients significantly, inhibit the local inflammatory response, reduce the immune globulin level of prostatic fluid, and adjust the local immune response. The clinical efficacy is superior to conventional western medicine.