To study the antihypertensive effect and mechanism of Sesame Lignan (SL) on renal hypertensive rats.Methods:Male SD rats were selected as experimental animal and randomly divided into sham surgery group, model group and SL group.The model of renovascular hypertensive rats was established and given 10 mg/kg/d Sesame Lignan for intervention.After intervention, blood pressurelevels, oxidative stress and endothelial function were measured.Results:In 3 weeks, 4 weeks, 5 weeks and 6 weeks after intervention, MBP levels of model group were significantly higher than sham surgery group.MBP levels of SL group were significantly lower than model group; 6 weeks after intervention, AOPP, MDA contents in kidney and AOPP, MDA,ET-1 contents in serum of model group were significantly higher than sham surgery group.SOD, GSH-Px contents in kidney and SOD, GSH-Px, NO contents in serum were significantly lower than sham surgery group; AOPP, MDA contents in kidney and AOPP, MDA, ET-1 contents in serum of LS group were significantly lower than model group.SOD, GSH-Px contents in kidney and SOD, GSH-Px, NO contents in serum were significantly higher than model group.Conclusion:Sesame Lignancan reduces blood pressure level of renal hypertensive rats by inhibiting oxidative stress and reducing vascular endothelium damage.