To observe the macro and physicochemical changes of hypertensive rats with live-fire hyperactivity syndrome under stress, to evaluate the effects of stress in the process of hypertension, expounds the theoretical basis of liver governing the free flow of qi.Methods:Stress with same intensity was given to hypertension rats with liver fire hyperactivity (SHR 14-18 weeks old) and normal rats (Wistar at the same age). The blood pressure, irritability degree, behavior and content of Ang-II and NE in serum were dynamically meassured. The difference and correlation for multiple dimensions were analyzed.Results:The adaptability to stress of hypertensive rats with liver-fire hyperactivity was worse than normal rats. Compared with non-stress group of SHR, the pressure increased significantly (P<0.05), and score of irritability degree was higher (P<0.05). The contents of Ang-II and NE in the blood was increased (P<0.05), and 2 weeks after the stress stopped，the above indexes were still significantly higher than non-stress SHR (P<0.05). Although the indexes of normal Wistar Rats under stress increased (P<0.05), but compared with the SHR which appeared in the late stage of stress later, and the indicators returned to normal level 2 weeks after stress stopped, and there was no significant difference (P>0.05).Conclusion:In normal physiological conditions, liver function is normal. The body can make adaptive response if affected by external stress in a certain extent, but under dysfunction of the liver, stress injury will occur, the mechanism of which may be related to the content increase of NE and Ang-II.