To study the effect of acupuncture combined with Liangxuexiaocuoyin on Heat-Damp Syndrome acne and their influence on TNF-α and IL-6.Methods:A total of 90 cases of Heat-Damp Syndrome acne patients in our hospital during June 2014 to December 2016 were chosen as research subject.According to the random number table method, all patients were divided into control group and observation group, with 45 cases in each.Patients in control group were treated with Liangxuexiaocuoyin only and those in observation group were treated with acupuncture combined with Liangxuexiaocuoyin.The treatment effect, serum hormone levels, contents of TNF-α and IL-6 in two groups were compared.Results:Total efficiency in observation group was higher than that in control group (P<0.05); After treatment, serum contents of hormones such as LH, and E2 were higher than those in control group, and testosterone was significantly lower than that in control group; serum contents of inflammatory factors such as TNF-α and IL-6 were lower than those in control group (P<0.05).Conclusion:Acupuncture combined with Liangxuexiaocuoyin can significantly improve treatment effects of Heat-Damp Syndrome acne patients, optimize hormone levels and reduce systemic inflammatory response.