To observe and analyze the clinical efficacy of 36 cases of primary hepatic carcinoma (PHC) treated with puncturing liver meridian combined with loading microspheres. Methods:A total of 36 cases with PHC in our hospital from September 2015 to May 2016 were enrolled as control group and received intervention microspheres treatment measures, with the basic research object for the observation group and the control group in the combined acupuncture and Chinese medicine treatment of 36 patients were included in our hospital during the period from June 2016 to February 2017 were of primary hepatocellular carcinoma. The blood routine, liver function and adverse reactions of the two groups were observed and analyzed. Results:After treatment, the decrease of white blood cells and red blood cells, platelets of observation group was significantly better than the control group, and the difference was statistically significant (P<0.05); The improvement of liver function of patients in the observation group after treatment was significantly better than the control group (P<0.05); The clinical efficacy of the observation group was 88.89% (32/36), which was higher than that of the control group (69.44%, 25/36), and the difference was statistically significant (P<0.05); the incidence of adverse reactions in observation group was significantly lower than the control group (P<0.05). Conclusion:Acupuncture puncturing liver meridian combined with drug loaded microspheres in the treatment of primary liver cancer has a significant clinical efficacy with high safety, fewer adverse reactions, and it is worthy of clinical promotion.