To explore Professor Li Shunmin's Traditional Chinese medicine (TCM) diagnostic and treatment patterns in chronic renal failure. Methods:Clinical records between May 2012 and March 2017 of patients diagnosed with chronic renal failure were collected. A thorough search on chronic renal failure papers was performed through China Network Knowledge Infrastructure (CNKI) database, and famous physician experience papers were selected for analysis. TCM pathologic factors, symptoms, syndrome pattern, treatment principles, and herb usage results were mined from the selected papers before being processed and subjected to one-dimensional and two-dimensional analysis, Network diagrams were visualized using Cytoscape. Results:Professor Li Shunmin regularly used Radix Astragali, Rhizoma Dioscoreae, Radix et Rhizoma Glycyrrhizae Praeparata cum Melle, Radix et Rhizoma Rhei, Herba Cistanches, Radix et Rhizoma Salviae Miltiorrhizae, Folium Perillae, Semen Euryales, Rhizoma Atractylodis Macrocephalae and Radix Rehmanniae in the treatment of chronic renal failure. Warm, neutral, cold, sweet, bitter and acrid were the most frequently used herb properties. The main pathologic factors were turbid dampness, blood stasis, dampness heat, dampness water, weakened body resistance and dietary factors. Main symptoms were edema, weakness, nausea and vomiting. Main syndrome pattern was spleen and kidney deficiency. Main treatment principles obtained were blood invigorating stasis dissipating and tonifying the spleen and kidney. Most commonly used herbs were Radix et Rhizoma Rhei, Radix Astragali, Radix Angelicae Sinensis, Poria, Radix Rehmanniae, Radix et Rhizoma Salviae Miltiorrhizae, Rhizoma Atractylodis Macrocephalae, Rhizoma Pinelliae, Rhizoma Coptidis, Scorpio. Conclusion:Through data mining, both Professor Li Shunmin's diagnostic and herbal prescribing patterns were analyzed. Famous physician papers were collected and analyzed, followed by result comparison with that of Professor Li Shunmin's. Through these comparisons, the unique characteristics were derived, such as tonfying the spleen, strengthening the spleen, tonifying qi, tonifying kidney yang, purgating, blood invigorating stasis dissipating, relieving external syndrome and essence controlling in Professor Li Shunmin's chronic renal failure treatment.