To observe clinical curative effects of Taohe Chengqi Decoction on endometriosis, and to analyze the significance of changes of sex hormone, ovarian function, and vascular endothelial growth factor (VEGF) before and after treatment. Methods: A total of 80 cases of patients with endometriosis who were admitted and treated in Luoyang Central Hospital Affiliated to Zhengzhou University were randomly divided into the control group and the observation group. The patients of control group were treated with oral administration of danazol, since 1st day of menstruation, 200 mg/time, bid, continuous treatment for 6 months. Patients of observation group were treated combined with Taohe Chengqi Decoction on the basis of the above treatment, 1 dose per day, 200 mL warm decoction was taken in the morning and evening, continuous treatment for 6 months. The changes of indicators of two groups including TCM syndrome integrals, sex hormone, and ovarian function and VEGF concentration were observed before and after treatment. Results: The clinical total effective rate of the observation group was 92.5%, and the control group was 85%, which had statistical significance (P<0.05). After 6 months of treatment, the TCM syndrome integrals of two groups were decreased. TCM syndrome integrals of the observation group after treatment were significantly lower than the control group, and the differences were statistically significant (P<0.05). After treatment, estradiol and progesterone levels in patients of the two groups were lower than before treatment and the differences were statistically significant (P<0.05). It was found that the observation group reduced more significantly, compared with the control group, with statistically significant differences (P<0.05). Follicle diameter and follicle growth average speed of the observation group 1 day before ovulation were better than those in the control group, and the differences were statistically significant (P<0.05); During the luteal phase/follicular phase, PSV of ovarian basal artery in the observation group were significantly higher than that in the control group, and the PI and RI were significantly reduced than that in the control group, and the differences were with statistical significance (P<0.05). VEGF levels of peripheral blood decreased in the two groups after treatment, and the decrease of the observation group was more significant. The differences were with statistical significance (P<0.05). Conclusion: Taohe Chengqi Decoction can significantly improve the ovarian function of endometriosis, and the mechanism may be associated with reducing the levels of VEGF.