To investigate the clinical curative effect of small dose of peritoneal dialysis combined with Shenling Baizhu Granules in treatment of uremic patients. Methods: A total of 64 patients with peritoneal uremia were admitted and treated in Panjin Central Hospital of Liaoning Province from May 2014 to May 2017 and randomly divided into Chinese medicine group and control group according to random table method, with 32 cases in each group. The patients in Chinese medicine group were treated with small dose of peritoneal dialysis combined with Shenling Baizhu Granules, and those in control group were treated with conventional peritoneal dialysis, continuous treatment for 6 months. The biochemical indexes of two groups including TCM symptoms, hemoglobin (Hb), albumin (Alb), total protein (TP), urea nitrogen (BUN) and serum creatinine (Scr) were compared, and the amount of urine was recorded. The peritoneal dialysisurea clearance index (KT/V) was caculated. Results: The improvement of TCM symptoms in Chinese medicine group was significantly better than that in control group, and the difference was statistically significant (P<0.05); There were no significant differences of BUN and Scr in Chinese medicine group before and after treatment (P>0.05). After treatment, the indexes of Hb, Alb, TP and urine volume in Chinese medicine group were significantly higher than those in control group, and the differences were statistically significant (P<0.01); After treatment, there was no significant difference in KT/V between Chinese medicine group and control group (P>0.05), and the peritoneal KT/V was significantly higher than that in the control group, and the difference was statistically significant (P<0.01); After treatment, the quality of life in Chinese medicine group was significantly higher than that in control group, and the difference was statistically significant (P<0.05); Body mass index (BMI) and triceps skinfold thickness (TSF) in Chinese medicine group were significantly higher than those in control group after treatment, and the differences were statistically significant (P<0.05). Conclusion: Small dose of peritoneal dialysis combined with Shenling Baizhu Granules can not only reduce the cost of treatment, improve the biochemical indexes of patients, and improve the symptoms of patients, optimize the quality of life and the nutritional status of patients, which is worthy of promotion.