To investigate the clinical efficacy of traditional Chinese medicine combined with western medicine in the treatment of acute calculous cholecystitis and its effects on blood coagulation. Methods: A total of 86 patients with acute calculous cholecystitis were admitted and treated in Shanghai Tenth People's Hospital from July 2016 to July 2017 and were randomly divided into the observation group (43 cases) and the control group (43 cases). Two groups of patients were treated with laparoscopic cholecystectomy after admission. The patients in the control group were given anti-infection, correcting acid-base balance, correcting water and electrolyte disturbance, gastrointestinal decompression and anti-inflammatory and cholagogic treatment after operation. The observation group was treated with Chinese medicine decoction on the basis of the therapies in the control group. Both of the two groups were treated for 7 days. The therapeutic effects, the changes of blood coagulation indexes and inflammatory factors, the time of abdominal pain relief and the recovery time of leukocytes were compared between the two groups. Results: The total effective rate of the observation group (95.35%) was higher than that of the control group (76.74%) (P<0.05). Prothrombin Time (PT) and activated partial thromboplastin time (APTT) increased in the two groups after treatment (P<0.05), and PT and APTT indexes in the observation group were higher than those in the control group (P<0.05). Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels decreased in two groups after treatment (P<0.05); and IL-6 and TNF-α levels in the observation group were lower than those in the control group after treatment (P<0.05). The relief time of abdominal pain and the recovery time of WBC in the observation group were faster than those in the control group (P<0.05). Conclusion: The clinical effect of the treatment of acute calculous cholecystitis with traditional Chinese medicine combined with western medicine is significant and it can improve the blood coagulation status of patients, which has important research significance.